Tailored Solutions for Pain-Related Clinical Trials

Maximizing Clinical Trial Success with the Power of Thermal QST 

Demonstrating efficacy of new analgesics in the context of clinical trials is challenging.Among the reasons is the high variability in patient response. Recent studies, however, offer room for optimism. These new findings support the notion that phenotyping and stratifying patients by their Sensory Profile can predict treatment response. Employing thermal Quantitative Sensory Testing (QST) methods offers precise, reliable data that facilitates phenotyping patients with a higher likelihood of response to treatment, as well as to assess efficacy and safety. Utilizing QST in your trial will optimize the trial and maximize chances of success. Medoc offers neuro-diagnostic testing systems for the evaluation of small sensory nerve fibers and the characterization of pain mechanisms. These systems include both QST and Contact Heat Evoked Potential (CHEPS) techniques. These methods assess the integrity of sensory fibers by determining pain and sensation thresholds for cold and warm temperatures, as well as vibration sensation thresholds. Comparing the results to normative values of healthy subjects support classification based on the type of sensory impairment.

QST Expertise for Trial Success 

Utilizing capabilities of Medoc’s devices in the early phases of pain clinical trials can contribute significantly to the development of an optimal, robust study design in a pivotal trial, maximizing the chances that of trial success and your compound reaching its commercial market.

All-Phase Trial Advantages

Medoc’s devices have been utilized and integrated into all phases of clinical trials. In Phase I studies, Medoc devices are used to assess the analgesic effects of treatment based on subject’s response to experimental pain models. These are used to bridge the translational gap between animal models and patient population and produce first-in-human early efficacy measures. Medoc devices are also commonly used in both Phase II and III studies at baseline, to phenotype subjects based on specific characteristics as predictors of treatment response.


Q-Sense is a portable, easy-to-use system offering scientifically validated measures of warm, cool and heat-pain thermal sensory thresholds-all clinically useful determinants in the evaluation and monitoring of small- fiber neuropathies and neuropathic pain.

 Q-Sense CPM

Q-Sense CPM (Conditioned Pain Modulation) expands the testing scope of Q-Sense with an additional thermode within the same, lightweight system. This allows for the evaluation of multiple stimuli in advanced testing protocols as well as the ability to conduct both static and dynamic Quantitative Sensory testing.


  • Early design phase support - including research and guidelines
  • Recommendations for advanced QST test batteries and trial end-points
  • Streamlined, Plug & Play technologies - without time-consuming set-up procedures or complex operation
  • Customized software and reports - to a program/trial-specific protocol and needs
  • Training – covering all elements of QST performance in your trial, monitoring and protocol execution
  • Ongoing, Comprehensive Support

Hi, We Are Medoc

Medoc Ltd, Advanced Medical Systems is a leading innovator of diagnostic medical systems for clinics and research institutions around the world. With over 25 years of experience in the fields of pain research and neurological pathology, Medoc develops state-of-the-art systems in the fields of thermal simulators and QST