• Pain goes through the stomach for veterans with Gulf War Illness

    10 November 2019

    Gulf War Illness (GWI) is presented by a number of health symptoms, among them pain complaints and gastro-intestinal (GI) issues in returning veterans who have served in the Persian Gulf War.

    A study by Zhou et al. from 2018 utilizing Medoc’s TSA-II used QST and compared between veterans suffering from GWI with GI complaints (GWI+GI), veterans with GWI without GI complaints, and healthy veterans. The experimental pain tests comprised of: Heat Pain Threshold, Cold Pressor Threshold, Ischemic Pain Threshold and Ischemic Pain Tolerance. Veterans with GWI+GI had significantly lower heat pain thresholds and cold pressor thresholds as compared to healthy veterans and veterans with GWI but no GI symptoms. There was no significant difference between healthy veterans and veterans with GWI but no GI symptoms. For the ischemic pain threshold and tolerance test both GWI veterans groups reached their respective levels before the healthy veterans. Moreover, average daily abdominal pain in GWI+GI veterans was significantly correlated with the experimental pain measures. These findings of increased pain sensitivity and their connection to GI symptoms in GWI veterans may point to convergence of visceral and somatic pain pathways, authors hypothesize.

    Source: Zhou, Q., Verne, M. L., Zhang, B., & Verne, G. N. (2018). Evidence for somatic hypersensitivity in veterans with Gulf war illness and gastrointestinal symptoms. The Clinical journal of pain, 34(10), 944-949.

    Picture source: Wikimedia Commons, U.S. DOD

    For the full-text article:

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  • Are headaches common due to lacking conditioned pain modulation (CPM)?

    29 July 2019

    This question motivated Levy et al. to investigate the endogenous inhibition efficiency of the trigeminal and extra-trigeminal areas of the face, neck, and arm in healthy volunteers. Two TSA devices were used to allow thermal test and conditioning stimulation within these areas. CPM was tested in three different zones; 1) forehead (V1) and cheek (V3), 2) cheek and neck (C4), and 3) neck and arm (C7). Additionally, spatial summation of pain (SSP) and temporal summation (TS) of pain were tested on all four areas.

    Interestingly, the forehead was found to be least sensitive to heat pain, requiring the highest temperature to reach a VAS 5-6 pain rating. The only configuration that yielded a significant CPM response, was the neck and arm set-up, which did not involve any of the trigeminal sites. Spatial summation of pain was elicited in all four sites, and post-hoc analysis showed less spatial summation of pain in the forehead as compared to the other regions. Temporal summation of pain did not differ significantly between sites.

    This study showed inefficient pain modulation in trigeminal, as compared to extra-trigeminal areas. These findings could point to a possible factor in the etiology of pain syndromes involving the trigeminal area.

    To study CPM with two thermodes, you no longer need two TSAs, Our new TSA2, comes with standard dual-thermode abilities, allowing for advanced thermal stimulation protocols, with one portable device!

    For the article abstract:

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  • Is polyneuropathy reversible?

    18 June 2019

    A new study by Ng Wing Tin et al. suggests it might be.


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  • Medoc will exhibit at NeuPSIG 2019

    21 April 2019

    Medoc Ltd. will exhibit at The 7th International Congress on Neuropathic Pain (NeuPSIG 2019), the international forum that provides the latest research and developments in understanding the mechanisms, assessment, prevention and treatment of neuropathic pain.

    The conference will be held this year on May 8-11 in London, and will focus on Diabetic Neuropathic Pain and Chemotherapy-induced Peripheral Neuropathic Pain.

    Join our MINI Symposium:

    “The use of Quantitative Sensory Testing in pharma-sponsored analgesic clinical trials: insights from recent trials” by Roi Treister. May 10th 12:45 at the Buckingham Room

    Attend the QST Workshop with Medoc devices:

    Hands-On workshop with leaders in the pain study field. May 10th 15:30-18:30 at the Windsor Suite


    You’re welcome to visit us at our Booth #202

    For the NeuPSIG scientific program


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  • Thermal quantitative sensory testing proves pre-clinically relevant in type 2 Diabetes

    14 March 2019

    Thermal Quantitative Sensory testing (QST) is routinely performed in various diabetes clinics around the world to monitor for small fiber abnormalities.


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  • Could Quantitative Sensory Testing help protect cancer patients from neuropathy?

    7 February 2019
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    QST testing may detect subclinical neuropathy and hence, treatment may be adjusted in time.


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  • QST identifies the better surgical skin graft technique

    24 January 2019
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    QST identifies the better surgical skin graft technique:

    In a recent article published in the International Journal of Surgery, authors reported the use of a wide array of QST (quantitative sensory testing) techniques to identify which of three surgical flap techniques is the least damaging to sensory nerve function of the donor site.

    In this trial, which used Medoc’s TSA II and AlgoMed QST systems, thirty-one patients were included, by approximation equally divided among three types of surgical techniques. (more…)

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  • Something to be optimistic about for 2019!

    2 January 2019
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    Computerized Pressure Algometer

    What do the AlgoMed device, conditioned pain modulation and optimism have in common?


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  • New technology may change the diagnosis and management of diabetic neuropathy

    15 November 2018
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    World Diabetes Day

    Diabetic neuropathy is one of the most common complications seen in patients suffering from diabetes worldwide, with rates of neuropathies seen in up to 50% of diabetic patients (Gordois et al., 2003a; Gordois et al., 2003b). Medoc has been developing different tools which, with the use of thermal and vibratory stimuli, are able to evaluate the type and level of impairment in different nerve fibers. (more…)

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  • AlgoMed – High Level Technology for Pain Diagnosis

    31 October 2018
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    Algometry has been used in the past decade for the detection of pressure pain threshold in different body sites, including bones, muscles and tendons. Patients with fibromyalgia, for instance, have been tested in clinical trials, attempting to quantify and characterize their pain through algometry. However, measurement tools adopted to test pain in fibromyalgia studies, for example, were based on the clinician’s impression of the patient’s state, thus not giving a precise measure (Cheatham et al., 2018).


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