• Are headaches common due to lacking conditioned pain modulation (CPM)?

    29 July 2019

    This question motivated Levy et al. to investigate the endogenous inhibition efficiency of the trigeminal and extra-trigeminal areas of the face, neck, and arm in healthy volunteers. Two TSA devices were used to allow thermal test and conditioning stimulation within these areas. CPM was tested in three different zones; 1) forehead (V1) and cheek (V3), 2) cheek and neck (C4), and 3) neck and arm (C7). Additionally, spatial summation of pain (SSP) and temporal summation (TS) of pain were tested on all four areas.

    Interestingly, the forehead was found to be least sensitive to heat pain, requiring the highest temperature to reach a VAS 5-6 pain rating. The only configuration that yielded a significant CPM response, was the neck and arm set-up, which did not involve any of the trigeminal sites. Spatial summation of pain was elicited in all four sites, and post-hoc analysis showed less spatial summation of pain in the forehead as compared to the other regions. Temporal summation of pain did not differ significantly between sites.

    This study showed inefficient pain modulation in trigeminal, as compared to extra-trigeminal areas. These findings could point to a possible factor in the etiology of pain syndromes involving the trigeminal area.

    To study CPM with two thermodes, you no longer need two TSAs, Our new TSA2, comes with standard dual-thermode abilities, allowing for advanced thermal stimulation protocols, with one portable device!

    For the article abstract:


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  • SOPATE 2019

    Medoc will attend The 3rd European Congress on Clinical Trials in Pain (SOPATE2019) which will take place on 26-27 November, 2019 in Amsterdam, The Netherlands.

    Click here for more info

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  • EFIC Congress – Valencia 2019

    The 10th Congress of the European Pain Federation - Medoc

    Medoc will participate at the 11th Congress of the European Pain Federation EFIC®. This will be held in Valencia, Spain from 4th to 7th September 2019. You’re welcome to visit us.

    Click here for more Info about this meeting.



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  • Medoc is excited to launch the TSA 2

    24 June 2019

    Medoc is excited to launch the latest advance in Thermal Pain Stimulation! Meet the TSA 2 Advanced Thermosensory Stimulator, enhanced speed and precision in a robust and portable device.


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  • Is polyneuropathy reversible?

    18 June 2019

    A new study by Ng Wing Tin et al. suggests it might be.


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